It is believed that its name derives from the neo-Assyrian Bit Gismeia. The Crusaders, who built a fortress in the village, called it Besmedin (1220 AD) and hence its current name Bishmizzine or Bechmezzine.

However, the area goes farther back in time to the Paleolithic/Mesolithic Age, according to archeological evidence that also includes findings of human settlements of the Bronze and Iron Ages.

Bishmizzine's history is also marked by the Byzantine era and the Islamic/Middle Age, also based on ruins and religious sites in the village. And there are many abandoned stone buildings in a number of areas of the village that were built by the British armed forces to serve as a rest and rehabilitation center for Allied Forces during World War II.

Back to the present, Bishmizzine is a wonderful village with an abundance of greenery, known for its friendly people and lively community life.